We conduct explorative toxicology studies to enable our customers to identify and define the safe therapeutic dose ranges for subsequent preclinical efficacy studies. Additionally, we perform screening studies that quickly and cost effectively identify which compounds are unlikely to succeed in further preclinical development.
Explorative preclinical toxicology studies are intended to assess the onset, severity, and duration of toxic effects, their dose dependency and degree of reversibility. They can encompass dosing regimens from acute (single dose) to chronic (multiple doses). Several routes of exposure (e.g., oral, intravenous, intramuscular, subcutaneous, topical, sublingual, etc) can be accommodated and multiple species (e.g., rodents, rabbits and minipigs) are available at our site enabling our customers to take the most optimal choice for their studies.
We are specialized in conducting comparative studies in which several compounds are administered to small number of rats or mice and limited toxicological assessments are carried out. These studies give an idea of relative toxicity and effect and facilitate selection of a limited number of candidate(s) for further investigation. We customize our studies to the individual client based on a range of study types:
- Dose range finding (DRF)
- Determination of maximum tolerated dose (MTD)
- Acute single dose toxicity
- Subacute, 7 or 14 days, repeated dose toxicity
- Local tolerance
- Implant tolerance
A full complement of toxicology evaluations are available, either through in-house resources or through strategic partnerships with external laboratories. These evaluations include clinical chemistry, hematology, urine analysis, histopathology, bioanalysis and toxicokinetics.
Please contact us with your specific request and questions.